Brain Volumetric Report

The Assessa Brain Volumetric Report provides a quantitative assessment of a number of structures including the hippocampus, amygdala, temporal horn and lateral ventricles; as well as a measure of atrophy in these regions from longitudinal scans. Left and right volumes are shown separately and displayed as a percentile of age matched controls. The Brain Volumetric Report also provides an Atrophy Index.

 

 

LEAP Analysis

Assessa is based on the Learning Embeddings for Atlas Propagation (LEAP) algorithm (Wolz et al, 2010).


 


 

LEAP has been shown to be able to predict time to dementia in subjects with MCI with an accuracy as good as manual volumetry and better than that of radiological scoring of medial temporal atrophy (van Rossum et al, 2012;Clerx et al, 2013;Vos et al, 2013). Not only can LEAP efficiently combine information from multiple brain structures to increase diagnostic confidence over that from using the hippocampus alone (Wolz and Rueckert, 2011;Wolz et al, 2013), but it has been shown to provide complementary information to an analysis of CSF Amyloid-Beta and Tau (Wolz et al, 2010).

LEAP was one of the algorithms included in the EMA qualification of Low  Hippocampal Volume as a biomarker to enrich clinical trials of AD in the pre-dementia phase (EMA 2011; Hill et al 2014). The test:re-test performance of the LEAP algorithm has been characterized both on repeat scans on a single scanner, and moving the subject between 1.5T and 3T scanners, showing the robustness of the method towards the typical variability in acquisition protocols found between different clinical centers (Wolz et al 2013b).

 


 

The Longitudinal Report

Assessa® integrates the LEAP and Longitudinal-LEAP algorithms (Wolz et al, 2010; Wolz et al, 2010b) which provide automated segmentation of the different brain structures at baseline and longitudinally. The brain atrophy report shows a longitudinal volumetric index that takes into account both the baseline and follow-up regional volumes. The change over time is represented by a “change from first assessment” report which shows the change from baseline and follow-up. 

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